Author
Junqiang Fan
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Recent research
- BiologyOpen access
A canonical role of SMAD4 in safeguarding 3D genome architecture to suppress lung tumorigenesis
Dysregulation of three-dimensional (3D) genome architecture is a hallmark of cancer, yet the mechanisms by which its disruption drives tumorigenesis remain incompletely understood. Here, we demonstrated that SMAD4 regulated 3D genome organization through its canonical transcripti...