Junpeng Huang

Multi-omics bioinformatic screening identifies PFDN2 as an obesity-correlated molecular target of triple-negative breast cancer

Abstract Triple-negative breast cancer (TNBC) is characterized by high malignancy, poor prognosis and a lack of specific therapeutic targets. Obesity acts as a major risk factor facilitating TNBC progression, while the molecular features underlying their correlation remain poorly...

Single-cell analysis reveals immunotherapy-induced epithelial state remodeling and identifies PLAUR as a prognostic biomarker in colorectal cancer

Immune checkpoint blockade has achieved durable responses in a subset of colorectal cancer (CRC) patients; however, the majority derive limited benefit. While previous studies have largely focused on immune cell dynamics, how tumor epithelial cells adapt to immune selection press...