Junjie Wu

Nicotinamide N-methyltransferase in tumor stroma–immune crosstalk: Metabolic–epigenetic mechanisms and translational opportunities

Nicotinamide N -methyltransferase (NNMT) transfers a methyl group from S-adenosylmethionine to nicotinamide, generating 1-methylnicotinamide (1-MNA) and S-adenosylhomocysteine and thereby linking nicotinamide disposal, nicotinamide adenine dinucleotide (NAD + ) salvage, and methy...