Jung Moo Lee

TRANsCre-DIONE transdifferentiates scar-forming reactive astrocytes into functional motor neurons

Abstract In spinal cord injury (SCI), the scar-forming reactive astrocytes with upregulated glial fibrillary acidic protein (GFAP) proliferate aberrantly near the injury site, representing a potential cellular source for transdifferentiation into neurons to replenish dead neurons...