Jun Zhao

Machine Learning-Guided Discovery of Natural BACE1 Inhibitors with Enzymatic and Cellular Validation

Abstract Alzheimer’s disease (AD) is a progressive neurodegenerative disease characterized by excessive accumulation of β-amyloid (Aβ) peptides in the brain. Beta-secretase 1 (BACE1), the rate-limiting enzyme in the amyloidogenic processing pathway of amyloid precursor protein (A...

ASFV D117L hijacks KEAP1 to induce oxidative stress-dependent vascular endothelial cell death

African swine fever (ASF), caused by the ASF virus (ASFV), is a fatal hemorrhagic disease of domestic pigs that causes significant economic losses in the global pig industry. Systemic hemorrhages and abnormal coagulation of multiple tissues and organs are the typical lesions of A...