Jun-Ying Ou

Structural and Biochemical Analysis of Human Schlafen5 Reveals the Molecular Basis of Its Anti-Tumor Function

Background: Schlafen5 (SLFN5) is an IFN-inducible member of the SLFN protein family involved in immune regulation, viral inhibition and tumor control. Recently, SLFN5 was suggested to inhibit the invasion of many kinds of malignant cells, and its expression positively correlates...