Jun Lao

Context-Dependent Roles of the Plexin-B Family Across Neurological, Oncological, Immune and Cardiovascular Disorders: Mechanisms and Therapeutic Implications

Plexin-B1, Plexin-B2, and Plexin-B3 are members of the Plexin-B receptor family, which engage distinct class IV semaphorins as major ligands: Plexin-B1 binds SEMA4D, Plexin-B2 interacts with SEMA4C and SEMA4B, and Plexin-B3 has been reported to bind HSPA5, while all three may par...