Jun-Guang Chen

Enhanced acetate uptake and metabolism in endothelial cells promote tumour angiogenesis and immunosuppression by increasing histone acetylation

Background Acetate is the metabolic precursor of acetyl-coenzyme A (CoA), fuelling histone acetylation. Objective We aimed to investigate whether the acetate-acetylation axis is hijacked in tumour endothelial cells (TECs) to govern hepatocellular carcinoma (HCC) progression. Desi...