Juliette Froelich

Preliminary Evaluation of Synthetic Amanitin Analogs as Novel Payloads for Potent Antibody−Drug Conjugates

Abstract Alpha-amanitinthe principal toxin of Amanita phalloides, infamous for its hepatotoxicity and lethalityhas been receiving considerable attention as a candidate payload in antibody−drug conjugates (ADCs). Previously, we identified three synthetic amatoxins with heightene...