Julieta L. Sacchetto

Synthon-Based Crystal Engineering of Mebendazolium Tosylates: Solid-Form Design, Structure−Property Relationships, and Enhanced Solubility from Experimental and DFT Studies

Abstract Salt formation is a well-established crystal engineering strategy to modulate the physicochemical and pharmacokinetic properties of active pharmaceutical ingredients. In the case of mebendazole (MBZ), a broad-spectrum anthelmintic, this approach has been successfully emp...