Julien Pompon

Systematic interactome analysis identifies OCRL as a DENV 2 NS4A interactor that inhibits viral replication through a mechanism independent of global actin cytoskeleton rearrangement

Dengue virus (DENV) is a medically important human pathogen belonging to the genus Orthoflavivirus . DENV encodes seven non-structural (NS) proteins which exert multiple cellular effects. NS4A is a 16 kDa membrane-associated protein; however, its functions in orthoflavivirus infe...

Multiple orthoflaviviruses secrete sfRNA in mosquito saliva to promote transmission by inhibiting MDA5-mediated early interferon response

Abstract Numerous orthoflaviviruses transmitted through the bites of different mosquito species infect more than 500 million people annually. Skin infection at the bite site represents a critical and conserved step in transmission and a deeper understanding of this process will p...