Julien L. P. Morival

Reducing Nuclear Rupture Rescues Gene Expression and Survival in LMNA -DCM

BACKGROUND: Mutations in the LMNA gene, which encodes the nuclear envelope proteins lamins A and C, account for 6% to 8% of all cases of congenital dilated cardiomyopathy. LMNA -related dilated cardiomyopathy is among the most severe forms of dilated cardiomyopathy, with limited...