Julia Shevchenko

Gestational stage and fetal allogeneity shape cytokine and cytokine receptor isoform expression in the murine placenta

Abstract Pregnancy requires the maternal immune system to tolerate a semi-allogeneic fetus while preserving the capacity to respond to infection, yet how alternative transcript isoforms contribute to immune regulation at the maternal–fetal interface remains poorly understood. Her...

Multimodal profiling of HER2/neu-specific TCR-T cells reveals clonotype-dependent activation programs underlying differential cytotoxic efficacy

Abstract Adoptive T cell therapy targeting tumor-associated antigens offers a promising avenue for cancer immunotherapy, yet the mechanisms underlying functional heterogeneity among T cell receptors recognizing the same antigen remain poorly understood. Here, we comprehensively p...