Juan Zhang

Polyendocrine metabolic ovarian syndrome (PMOS, formerly Polycystic Ovary Syndrome): a systems-biology perspective on neuroendocrine, immuno-metabolic and epigenetic mechanisms across the life course

Polyendocrine metabolic ovarian syndrome (PMOS) is the name adopted in 2026 by the Global Name Change Consortium for the condition previously called polycystic ovary syndrome (PCOS); diagnostic criteria are unchanged, and a managed three-year transition to the new terminology is...

HomocamptothecinPayloads with Enhanced Potency forAntibody-Drug Conjugates

Abstract Camptothecin derivatives, exemplified by DXd, are a dominant class of payloads for antibody-drug conjugates (ADCs). Herein, we describe the design and synthesis of H2, a novel homocamptothecin featuring a simplified hydroxybutyl structure that circumvents the complex ass...