Juan Manuel Sepúlveda

Rethinking CAR-T neurotoxicity in glioblastoma: immune activation within a preconditioned neuroinflammatory landscape

Abstract Chimeric antigen receptor (CAR) T-cell therapy has reshaped the treatment of hematologic malignancies, leading to remarkable responses in diseases that were once considered largely refractory. However, its translation to solid tumors, and particularly to glioblastoma (GB...