Józef Dulak

Endothelial senescence impairs efferocytosis and alters macrophage responses: insights into APP-CD74 signaling

Abstract Background Endothelial cell senescence contributes to vascular aging and chronic inflammation, yet its impact on endothelial–macrophage interactions remains poorly understood. Here, we combined functional assays, global proteomics, 3D co-culture spheroid models, and sing...

Gene-Corrected Human iPSC–Derived Cardiomyocytes and Skeletal Muscles Reveal Partial Dystrophin Dp427 Preservation and Cardiac Dp116 Expression in Duchenne Muscular Dystrophy Patient With a Splice-Site Mutation in Intron 68 (c.9975-1G>T)

BACKGROUND: Duchenne muscular dystrophy (DMD) is a severe X-linked neuromuscular disease caused by mutations in the DMD gene, leading to the absence or dysfunction of dystrophin. Although cardiac and skeletal muscles are both affected, tissue-specific differences in disease manif...