Joshua Hutchings

Multiscale physical effects of CpG methylation on DNA mechanics, nucleosome wrapping, and chromatin condensates

DNA methylation at CpG dinucleotides is a central epigenetic modification linked to transcriptional repression and heterochromatin formation, yet its physical impact on chromatin organization remains incompletely understood. Here, we integrate single-molecule force spectroscopy,...

Lessons learned from a Kaggle challenge for particle picking in cryo-electron tomography

Abstract The difficulty of particle picking in cryo-electron tomography remains a barrier to routine in situ structure determination. Machine learning is well-suited to overcome this bottleneck with efficient algorithms that generalize across molecular species. To spur new algori...