Joshua D. Grill

Plasma Phosphorylated Tau 217 Percentage by Race and Ethnicity in Preclinical Alzheimer Disease

Importance In trials targeting preclinical Alzheimer disease (AD), defined as amyloid pathology without cognitive symptoms, racial and ethnic differences in plasma phosphorylated tau 217 percentage (%p-tau217) may influence screening eligibility. Objective To characterize racial...

Case-cohort designs to improve efficiency for detecting effect modification

Abstract In analyses of time-to-event outcomes, we may utilize efficient sampling designs to save effort, cost, and valuable specimens. The originally proposed case-cohort design is one such design, and performs analysis on a random sample selected from the full cohort supplement...