Josh F. Peterson

An artificial intelligence framework for end-to-end rare disease phenotyping from clinical notes using large language models

Phenotyping is fundamental to rare disease diagnosis, but manually curating structured phenotypes from clinical notes is labor intensive and difficult to scale. Existing artificial intelligence (AI) approaches optimize individual components of phenotyping but generally do not ope...

Integrating genetically predicted transcriptomic signatures with longitudinal real-world data for drug repurposing in Alzheimer’s disease

Drug repurposing offers a potential strategy to expand treatment options for conditions with limited therapies, but advancing repurposing candidates toward clinical implementation remains a challenge. Large-scale data, together with advanced genetic and epidemiological methods, m...

Tramadol Co‐Administration with Oxycodone or Hydrocodone Increases Opioid Burden without Improving Postoperative Pain Control

Tramadol is frequently co-prescribed with oxycodone or hydrocodone after surgery under the assumption that its dual mechanism of action provides an opioid-sparing benefit. However, evidence supporting this practice is limited and inconsistent. We conducted a secondary analysis of...