Joseph T. Chang

Targeting a miRNA–mRNA regulatory network to overcome radioresistance in head and neck cancer: identification of I-OMe-AG-538 via transcriptome-guided drug repurposing

Abstract Radioresistance is a major obstacle to successful radiotherapy in head and neck cancer (HNC), leading to treatment failure, recurrence, and poor patient outcomes. MicroRNAs (miRNAs) are key post-transcriptional regulators implicated in radiosensitivity, but comprehensive...