Joseph Irudayaraj

Parent-of-origin dependent allelic regulation of social behaviors in mice by noncanonically imprinted monoamine synthesis genes

Monoamine neurotransmitters are central regulators of social behavior, yet it is unknown whether genomic imprinting of genes within their signaling pathways modulate these behaviors. The monoamine synthesis genes tyrosine hydroxylase (Th) and dopa decarboxylase (Ddc) exhibit tiss...

The urinary pathobiont Actinobaculum massiliense can generate androgens via the dirAB pathway

While overlooked during the Human Microbiome Project, characterizing the urinary microbiota in health and disease is a new frontier in microbiome science. Recent studies have associated differential abundance of bacterial taxa including Propionimicrobium lymphophilum and Actinoba...

The urinary tract commensal Peptoniphilus spp. encodes a novel 17β-hydroxysteroid dehydrogenase

ABSTRACT Microbial steroid metabolism represents an underappreciated extension of the vertebrate endocrine system, with growing evidence that host-associated microbes contribute to the diversity and bioavailability of sex steroids to human tissues. Emerging studies have linked mi...