Josef Sýkora

Retinoid biology from embryonic patterning to adult tissue homeostasis: metabolism, RAR signaling, disease mechanisms, and clinical translation

Vitamin A gives rise to functionally distinct retinoids that regulate vision, embryonic patterning, and adult tissue homeostasis. The principal endogenous transcriptional ligand, all-trans-retinoic acid (ATRA), activates RARα, RARβ, and RARγ within RAR-RXR heterodimers; this mech...