Jose Manuel Sanchez-Manas

Cargo-specific platelet reprogramming and education mediated by pancreatic cancer-derived extracellular vesicles

The systemic progression of pancreatic ductal adenocarcinoma (PDAC) is tied to a hypercoagulable state, yet early tumor secretome–platelet interactions remain poorly defined. Prevailing models regard platelet education by tumor-derived extracellular vesicles (EVs) as a passive, d...