José L. Medina-Franco

Ser715 Phosphorylation Induces β-Hairpin Unfolding and Destabilization of FOXM1 Autoinhibition.

FOXM1 is a cell proliferation-driving transcription factor activated by phosphorylation-induced conformational changes. In its inactive state, an intramolecular β-hairpin within the transactivation domain (TAD) binds the N-terminal repressor domain (NRD), forming a composite β-sh...