José Eduardo Krieger

Capturing regional variation in aortic mechanics: dual-estimation method for material parameter identification and biological correlation

Abstract The aorta shows significant regional variation in geometry and composition. This complexity makes numerical modeling challenging, as it requires identifying material parameters. Typically, the Holzapfel-Gasser-Ogden model is used. However, it suffers from nonuniqueness a...

Systems biology analysis reveals miRNA–mRNA networks associated with cardiomyocyte responses to SARS-CoV-2 infection

Cardiac complications are common and clinically significant in COVID-19, yet their underlying molecular drivers remain poorly understood. Here, we integrate post-mortem histopathology with transcriptomic and microRNA (miRNA) analyses to delineate the regulatory architecture of SA...