José Alberto Rodrigues

Prior percutaneous coronary intervention versus deferral in patients undergoing transcatheter aortic valve implantation: a systematic review and meta-analysis of randomized controlled trials

Background Coronary artery disease (CAD) is highly prevalent among patients undergoing transcatheter aortic valve implantation (TAVI), yet the optimal management of concomitant coronary lesions remains uncertain. While routine percutaneous coronary intervention (PCI) prior to TAV...

Mathematical and computational modeling of head and neck cancer for personalized therapy

Abstract We present a coupled mathematical model for tumor progression and treatment-induced tissue remodeling in head and neck cancer. The framework links a reaction–diffusion equation for tumor cell density with finite-strain growth mechanics through a multiplicative decomposit...