Jorge R. Espinosa

RNA Synthesis and Degradation Regulate Biomolecular Condensates through Nonequilibrium Feedback

Abstract Transcriptional condensates operate far from equilibrium, where continuous RNA synthesis and degradation dynamically reshape condensate composition. To investigate how RNA synthesis regulates condensate properties at submolecular resolution, we introduce REACT-RNA, a che...

Near-atomistic simulations reveal the molecular principles that control chromatin structure and phase separation

Abstract Understanding how chromatin’s physicochemical properties shape its emergent organization is central to deciphering genome function. To address this, we present OpenCGChromatin, a high-performance coarse-grained model that achieves near-atomistic simulations of chromatin...

Antibody-drug conjugate engineering: from design to efficacy and safety

Antibody–drug conjugates (ADCs) represent a rapidly expanding class of targeted cancer therapeutics that combine the high selectivity of monoclonal antibodies with the potent cytotoxic activity of small-molecule drugs. Their clinical success relies on the simultaneous optimizatio...