Jorge Fragoso-Medina

Shared CI-linked bioenergetic dysfunction and muscle-specific lipid/redox stress in skeletal muscle of male cardiometabolic HFpEF mice

Exercise intolerance is a hallmark of heart failure with preserved ejection fraction (HFpEF), particularly in its cardiometabolic form, where obesity, metabolic dysfunction, and impaired peripheral oxygen utilization contribute to functional limitation. Skeletal muscle mitochondr...