Jonathan Mitchell

TM184C is a GPCR-like regulator of intercellular exchange and autophagy

Sequence similarity underlies most protein annotation, yet many functions remain hidden beyond detectable homology1–3. By mining millions of AlphaFold2 models4,5, we identify two human families of ‘superdark’ seven-transmembrane proteins—TM184 and PRRT—with structural homology to...