Jonathan Michael Retting

Identification of a Novel Druggable Pocket in the HIV-1 gp120 C5 Domain at the Conformational Relay Junction

HIV-1 entry requires a conformational relay that transmits the receptor-engagement signal to membrane fusion activation, yet no approved drug targets this transmission step. Here I report a novel druggable pocket in the gp120 C5 domain (Arg465-Arg472, sequence RPGGGDMR) at this r...