Jonathan M. Downie

Identification of prediagnostic proteomic biomarkers for colon and rectal cancer in 3 prospective cohorts

BACKGROUND: Large-scale proteomics may reveal circulating biomarkers of colorectal cancer (CRC) years before diagnosis, yet cross-cohort reproducibility and anatomic site-specificity remain unclear. METHODS: We conducted nested case-control studies in three prospective cohorts wi...