Jonathan Karn

HIV-1 Tat Forms a Dissociable Complex with 7SK snRNP and Exhibits Clade Differences in Reversing the Sequestration of P-TEFb

Recent efforts to employ ectopic Tat as a latency-reversal strategy can benefit from the identification of Tat variants with more efficient transactivation activity. Tat primarily serves as a recruiter of the host transcription elongation factor P-TEFb to proviral HIV to stimulat...