Jonathan Douxfils

Plasma p-tau217 in real-world clinical practice: distribution across clinical diagnostic categories, clinician confidence, and impact on care pathways

Plasma phosphorylated tau at threonine 217 (p-tau217) is a highly accurate blood-based biomarker for Alzheimer’s disease pathology, but evidence regarding its determinants and clinical impact in routine practice remains limited. We evaluated its distribution across real-world cli...

A multivariate plasma biomarker model for glioblastoma exclusion: a retrospective case-control study

Background Glioblastoma (GBM) remains the most aggressive primary brain tumour, with limited diagnostic tools able to capture its molecular heterogeneity in real time. Current clinical practice relies on MRI and invasive biopsies, which are poorly suited for early or dynamic dise...