John Ouyang

A somatic checkpoint through NHR-49/HNF4α governs reproductive investment and longevity in C. elegans

The nuclear hormone receptor NHR-49, a homolog of mammalian PPARα and HNF4α, is a key transcriptional regulator of nutrition sensing and fatty acid metabolism in Caenorhabditis elegans. Here, we examine the role of NHR-49 in reproduction, including oocyte activation and ovulation...