John J. Mekalanos

Actuation of CRP activating region 3 by formylation modulates the Vibrio cholerae response to oxidative DNA damage

The cyclic AMP receptor protein or CRP is a global regulator of bacterial metabolism. CRP activates transcription of genes required for utilization of alternative carbon sources in response to the second messenger cAMP, which is synthesized in the setting of glucose scarcity. Tra...