John F. O'Toole

Differential regulation of basal and interferon-induced APOL1 gene expression in podocytes

APOL1 genetic variants associated with kidney disease become pathogenic when APOL1 gene expression is induced to high levels, however, the mechanism of APOL1 gene regulation is not well characterized. Using human podocyte cell lines, the induction of APOL1 gene expression from va...