John Crary

Exploring transcriptomic and genomic latent variable correction approaches in differential expression analysis

Abstract Background Differential expression analysis is a central tool for studying the biological processes altered in human diseases via transcriptomic signatures. However, transcriptomic datasets are systematically confounded by latent variables from two distinct sources: unme...

A Combinatorial Twin-Prime Hierarchy Associated with the Fine-Structure Constant

This study investigates a combinatorial mathematical hierarchy associated with the inverse fine-structure constant (α⁻¹ ≈ 137.035999177), a dimensionless parameter fundamental to quantum electromagnetic theory. Rather than seeking a physical derivation of α, the analysis examines...