John C. Vederas

Synthesis of β‐Thiolated Amino Acids: Investigation Toward the Total Chemical Synthesis of Lasso Peptide Microcin J25

Microcin J25 (MccJ25) is of special interest due to its "lariat" topology. The lasso architecture is thought to be responsible for its remarkable thermal stability (100°C for 30 min incubation) and potency against Gram-negative bacteria (i.e., MBC of ~4.75 µM against E. coli stra...