John C. Chatham

Effects of Pharmacologically Induced Hyper-Protein O-GlcNAcylation on the Heart Transcriptome

Background/Objectives: O-GlcNAcylation is a post-translational modification affecting diverse cell functions, including transcriptional regulation. Aberrant levels of protein O-GlcNAcylation have been observed in neurodegenerative and cardiovascular diseases. We have previously d...