Johannes Grand

Early post-resuscitation profiles after out-of-hospital cardiac arrest: A latent class analysis

Background Early cardiopulmonary heterogeneity after out-of-hospital cardiac arrest (OHCA) may be associated with prognosis and treatment response. Objectives To identify early post-resuscitation profiles and explore their associations with outcomes and randomized treatment effec...

Acute heart failure in emergency settings

Abstract Acute heart failure (AHF) represents a major cause of emergency medical care worldwide and continues to carry a substantial burden of morbidity and mortality despite advances in chronic heart failure management. Most patients with AHF present to emergency departments (ED...

Adaptive platform trials: A revolution or a fleeting trend? A review of the strengths and limitations

Abstract Platform trials have gained significant attention in recent years, particularly during the COVID-19 pandemic, for their potential to deliver efficient and flexible clinical research. Designed to evaluate multiple interventions within a single, ongoing infrastructure, pla...