Jóhann E. Guðjónsson

Failed metabolic adaptation to stress contributes to epidermal cell adhesion defects in Darier disease

Congenital pathogenic gene variants may not elicit symptoms until later in life, highlighting the importance of identifying extra-genetic factors influencing the onset and severity of heritable diseases. We explored this in Darier disease (DD or ATP2A2 -nEDD), an autosomal domina...