Jóhann E. Guðjónsson

Utility of IL ‐18 Immunohistochemistry in Distinguishing Dermatomyositis and Lupus Erythematosus in Skin Biopsies

ABSTRACT Background Distinction of dermatomyositis ( DM ) and cutaneous lupus erythematosus ( LE ) in skin biopsies is often difficult due to significant histopathologic overlap. Prior transcriptional analysis has identified upregulation of IL ‐18 in DM compared with LE . We aime...

Failed metabolic adaptation to stress contributes to epidermal cell adhesion defects in Darier disease

Congenital pathogenic gene variants may not elicit symptoms until later in life, highlighting the importance of identifying extra-genetic factors influencing the onset and severity of heritable diseases. We explored this in Darier disease (DD or ATP2A2 -nEDD), an autosomal domina...