Joel N. Hirschhorn

Transcriptomic insights into diabetic kidney disease: a systematic review of RNA sequencing studies

Abstract Background Diabetic kidney disease (DKD) is a leading cause of chronic kidney disease and end-stage kidney disease worldwide. Despite shared clinical risk factors, substantial inter-individual variability exists in DKD susceptibility and progression, suggesting an import...

Accelerated Epigenetic Ageing in Diabetic Kidney Disease: A Comparison of 10 Epigenetic Clock Measures in Individuals With Type 1 Diabetes

To characterize accelerated epigenetic ageing in individuals with diabetic kidney disease (DKD) and type 1 diabetes, 10 epigenetic clocks were generated for those with type 1 diabetes, with (case patients) or without (control participants) DKD, within the All Ireland–Warren 3–Gen...