Jocelyn Sietsma Penington

Integrated signatures define mutational processes in prostate cancer

Prostate cancer follows a long and heterogeneous disease course with incompletely understood aetiology. Here, we dissect the mutational processes shaping the genomes of 959 donors from the Pan Prostate Cancer Group (PPCG) and assess their clinical relevance. By integrating de nov...

Dual plasmepsin IX and X inhibitors are refractory to development of resistance

Abstract Artemisinin-based combination therapies (ACTs) remain the cornerstone of malaria treatment, but emerging resistance threatens their efficacy. The potential for the development of drug resistance against plasmepsin X (PMX)-selective inhibitors and dual plasmepsin IX/X (PM...