João Marcelo de Castro e Sousa

A mechanistic approach about oxidative, mutagenic, and cytotoxic effects of an organotellurane

Abstract Organotellurium (OTe) compounds have pharmacological properties, including leishmanicidal, antimalarial, and antifungal activities. Herein, we assessed cytotoxicity effects of OTe RF07 in a panel of tumor cell lines, as well as its oxidative, toxicity, and hemolytic acti...

VLA-4 integrin modulates cellular responses to sorafenib in metastasis-related processes of B16F10 melanoma cells

Metastatic progression in melanoma is driven by the coordinated activity of adhesion molecules and growth factor receptors, yet the functional interplay between integrins and VEGFR-related signaling remains poorly defined. This study investigated the role of α4β1 integrin, also k...