João Alfredo Teodoro

Structural and Evolutionary Analysis of Non-specific Lipid Transfer Proteins (nsLTPs) in Cereus (Cactaceae)

The genus Cereus (Cactaceae), widely distributed across arid and semi-arid environments of South America, exhibits adaptive capacity that is partly associated with proteins involved in lipid metabolism and stress responses, such as non-specific lipid transfer proteins (nsLTPs). A...

Structure-Guided Discovery Reveals Recurrent Bioactive Peptide Architectures Across Coleoptera

Bioactive peptides are an important source of therapeutic molecules and molecular scaffolds involved in defense, signaling, and immune regulation. Despite the extraordinary diversity of Coleoptera, the structural landscape of beetle-derived bioactive peptides remains largely unex...

Integrative transcriptomic and machine learning approaches reveal candidate genes for silk and venom production in B ibionomorpha ( D iptera)

Insects display adaptive diversity in their secretory systems, which mediate ecological interactions ranging from defence to adhesion. Within Diptera, the co-occurrence of silk and venom represents a rare functional combination. Here, we integrate multi-species transcriptomics, c...