Joanna J. Phillips

Longitudinal single-cell and spatial profiling of sonic hedgehog medulloblastoma identifies novel therapeutic targets

Abstract Background Sonic hedgehog (SHH) medulloblastoma (MB) accounts for approximately one-third of all MB cases, the most common malignant brain tumor in children. Despite therapy, SHH MB relapse is frequent and has a dismal prognosis. New treatments for recurrent SHH MB are n...