Jinxiu Hou

Generation and characterization of a CEACAM5 x CDH17 x CD3 tri-specific T-Cell engager for colorectal cancer therapy

Abstract Background CEACAM5 and CDH17 are highly co-expressed in certain solid tumors including colorectal cancer (CRC). Current single-target based immunotherapies, such as antibody-drug conjugates (ADC) and T cell engagers (TCE), have shown promising efficacy in clinical trials...

Bifidobacterium pseudocatenulatum alleviates neonatal calf diarrhea via acetate-associated attenuation of pathogen-induced Th17/IL-17A inflammatory responses

Abstract Background Neonatal calf diarrhea is a major challenge in livestock production and is often driven by pathogen-induced intestinal inflammation and gut dysbiosis. While the therapeutic potential of Bifidobacterium ( B. ) pseudocatenulatum is recognized, its mechanistic in...