Jinna Zhao

Eudesmane Sesquiterpenoids from Dregea Volubilis Suppress Kidney Stones via Akt Signalling to Inhibit Oxalate Biosynthesis in Drosophila

Abstract Dregea volubilis has long been used in traditional medicine for the treatment of urolithiasis, yet its bioactive constituents and molecular mechanisms remain largely undefined. Here, molecular networking-guided UPLC-ESI-MS/MS analysis enabled the isolation of ten sesquit...