Jinlin Zhang

Identification of threonyl‐ tRNA synthetase as a potential fungicidal target of 4‐fluoro‐2‐aryl‐ 1H ‐indole

Abstract BACKGROUND Discovering novel pesticide targets based on newly synthesized compounds is of great importance for the development of new pesticides and sustainable agricultural. 4‐Fluoro‐2‐aryl‐1 H ‐indole (W1), a 2‐arylindole derivative obtained via one‐pot synthesis in ou...

Discovery of 3-Carboxyl-4-pyrazolamides as Promising Herbicidal Scaffolds Targeting Dihydroorotate Dehydrogenase

Abstract Enhancing innovation in herbicide discovery is imperative to combat weed resistance and safeguard global food security. To develop novel herbicide targeting dihydroorotate dehydrogenase (DHODH), a series of 3-carboxy-4-pyrazole amide lead scaffold bearing ester or acid s...

Venetoclax for elderly patients with acute myeloid leukaemia unfit for intensive chemotherapy: Prospects, resistance mechanisms and management strategies

To date, the treatment of acute myeloid leukaemia (AML) remains a major challenge in hematologic malignancies, particularly among elderly patients who are unfit for intensive chemotherapy. Venetoclax, a BCL-2 inhibitor, in combination with azacitidine, has significantly improved...