Jinhong Chen

SPATS2 triggers immune evasion and anti-PD-1 resistance of hepatocellular carcinoma by inducing dendritic cell phagocytic dysfunction

Abstract Background The clinical efficacy of anti-PD-1 immunotherapy in hepatocellular carcinoma (HCC) remains limited due to the inherently immunosuppressive tumor microenvironment. This study aims to investigate the role of the spermatogenesis-associated serine-rich protein 2 (...